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Image Search Results
Journal: Chinese Medicine
Article Title: Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit
doi: 10.1186/s13020-025-01230-x
Figure Lengend Snippet: EA suppresses neuroinflammation in the hippocampus of APP/PS1 mice by activating the β2-AR/PKA/CREB pathway. A Representative Western blots showing the levels of ADRB, PKA, p-PKA, CREB, p-CREB, IL-6, IL-1β, and TNF-α in the hippocampi of the mice in each group. B – I Data represent the mean ± SD (n = 4). * P < 0.05 and ** P < 0.01 by one-way ANOVA
Article Snippet:
Techniques: Western Blot
Journal: Neurochemical Research
Article Title: Morin Improves Cognitive Deficits in an in Vivo Model of Vascular Dementia by Modulating the N-methyl-D-aspartate Receptor Signaling Pathways
doi: 10.1007/s11064-026-04717-7
Figure Lengend Snippet: Morin modulated the expression of NMDA receptors in the hippocampus of VaD rats. a the expression levels of NR1 ; b the expression levels of NR2A ; c the expression levels of NR2B ; d the expression levels of NR1 protein; e the expression levels of NR2A protein; f the expression levels of NR2B protein; g protein levels of p-CREB; h protein levels of p-CAMK2A; i protein levels of p-CAMK2D. Protein levels of NR1, NR2A, and NR2B were quantified by ELISA. Data are presented as mean ± SD ( n = 8 per group). Statistical analysis was performed by one-way ANOVA with Tukey’s post-hoc test (data met assumptions of normality and homoscedasticity)/Kruskal-Wallis with Dunn’s test (data did not meet assumptions). * indicates a significant difference from the Sham group; # indicates a significant difference 2VO group; *# indicates a significant difference from both the Sham and 2VO groups, with a p-value of less than 0.05 considered statistically significant
Article Snippet: The phosphorylation status of another key NMDAR downstream effector, CREB at Ser133 (p-CREB), was quantified in hippocampal homogenates using a commercial
Techniques: Expressing, Enzyme-linked Immunosorbent Assay